From the wye junction and flat crossing (10 mph on the east and south quadrant connectors and flat crossing) with the line from Manassas Junction at Riverton Junction (MP 58.7/59.0), where there is a 14-car spur, the line turns north, and then north-northeast, past a detector at MP 58.1, a crossover at Ashby (MP 56.9/57.0), a 14,256 ft. siding, from Success (MP 53.1/.2), where there is a spur on the west side for the Virginia Inland Port, to Marsh Run (MP 51.9/52.0), Intermediate Signals at MP 48.5/.6, Intermediate Signals at Boyce (MP 45.9/46.0), a detector at MP 45.0, Intermediate Signals at MP 42.7/.8, a 5,280 ft. siding, from Berryville (MP 39.7/.8) to Audley (MP 38.5/.6), and Intermediate Signals at MP 36.1/.2.
The line crosses from Virginia into West Virginia, and passes Intermediate Signals at MP 32.7/.8, Intermediate Signals at MP 30.1/.2, a detector at MP 29.5, a flat crossing with the ex-B&O Harpers Ferry to Winchester line at Charlestown (MP 27.9/28.0), a connector to that line on the east side at Belt Junction, a 5,750 ft. siding from Daniels (MP 24.5/.6) to Shenandoah Junction (MP 22.7/.8), where there is a connector on the east side to the ex-B&O East End, a bridge over the former B&O, Intermediate Signals at MP 20.1/.2, a 6,684 ft. siding, from Morgan (MP 18.1/.2) to Shepardstown (MP 16.7/.8), where the line turns east, past a bridge over the Potomac River, turning north, past a detector at MP 14.4 and Intermediate Signals at Antietam (MP 14.3/.4).
There are Intermediate Signals at Mondel (MP 11.0/.1), Intermediate Signals at Grimes (MP 8.4/.5) adjacent to a bend on the river, to the west, Spielman, Intermediate Signals at St, James (MP 5.3/.4), a turn east-northeast and the start of double track at Vardo (MP 2.7/.8), and the junction between the CSX line from Winchester, and NS line from Front Royal (Riverton Junction), at Hager (MP 74.8), whence the Hagerstown Secondary heads northeast.